한약성분정보는 ‘운곡본초학 수재 한약재의 화학성분 제 2판(김정훈 외, 도서출판 우석, 2016)’의 내용을 발췌 및 정리하여 게시하였습니다. 해당 한약재에 함유된 성분 중 이차대사산물(secondary metabolites)을 주요 골격으로 구분하여 제시하였습니다 (성분의 골격 분류 방법에는 다양한 의견이 존재함을 일러드립니다).

관동화(款冬花)류 한약재의 기원 및 유통상황, 한방효능, 형태특징, 감별요점 등은 여기를 참조바랍니다.

written by : Jung-Hoon Kim. Division of Pharmacology, Pusan National Univ.

1. 관동화(款冬花): 관동(款冬) Tussilago farfara L.의 꽃봉오리(花蕾)

1.1. 꽃(花)

① Alkaloids: tussilagine, senkirkine

② Sesquiterpenes: tussilagone¹, tussilagin [14-acetoxy-7β-(3-ethylcrotonoyloxy)-notonipetranone], 14-acetoxy-7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-notonipetranone, 7β-(3-ethyl-cis-crotonoyloxy)-14-hydroxynotonipetranone, 14-acetoxy-7β-angeloyloxy-notonipetranone, 14-acetoxy-7β-senecioyloxynotonipetranone, 7β-(3-ethyl-cis-crotonoyloxy)-14-hydroxy-1α-(2-methylbutyryloxy)-notonipetranone, tussilagolactone, 7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone, tussilagonone, neotussilagolactone

③ Flavonoids: rutin, hyperin

④ Triterpenoids: faradiol, arnidiol

⑤ Steroids: β-sitosterol

⑥ Carotenoids: taraxanthin

⑦ Volatile compounds: 1-nonene, 1-octene, 1-undecene, 1-dodecene, 1-tridecene, 1-pentadecene, β-bisabolene, carvacrol, methyl palmitate, methyl linoleate, benzyl alcohol, phenylethyl alcohol, 1-nonen-3-ol, 1-undecen-3-ol, angelic acid, 2-methylbutyric acid

2. 봉두채(蜂斗菜): 머위(蜂斗菜) Petasites japonicus (Siebold & Zucc.) Maxim.의 지상부(全草)

2.1. 화경(花莖)

① Volatile compounds: 1-nonene, angelic acid, 1-undecene, 1-tridecene, 3-acetoxy-1-nonene, β-elemene, β-bisabolene, isoamyl alcohol, 3-hexen-1-ol, 1-nonen-3-ol, 1-linalool, veratrole, fukinone, β-caryophyllene, thymol methyl ether, petasitolone, 1,4,7-tridecatriene, p-cymene, 6β-angeloyloxy-3β,8α-dihydroxyeremophil-7(11)-en-12,8β-olide, 6β-angeloyloxy-3β,8β-dihydroxyeremophil-7(11)-en-12,8α-olide

② Sesquiterpene lactones: fukinolide, dihydrofukinolide, homofukinolide, S-fukinolide, fukinanolide, petasitin, isopetasin, fukinolic acid

③ Flavonoids: kaempferol, quercetin

④ Phenolic acids: caffeic acid, chlorogenic acid, fumaric acid

¹tussilagone(款冬酮, C₂₃H₃₄O₅)을 0.070% 이상 함유 _{[CP 2015]}