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대황(大黃) Rhei Radix et Rhizoma

대황(大黃) Rhei Radix et Rhizoma의 화학성분


한약성분정보는 ‘운곡본초학 수재 한약재의 화학성분 2(김정훈 외, 도서출판 우석, 2016)’의 내용을 발췌 및 정리하여 게시하였습니다. 해당 한약재에 함유된 성분 중 이차대사산물(secondary metabolites)을 주요 골격으로 구분하여 제시하였습니다 (성분의 골격 분류 방법에는 다양한 의견이 존재함을 일러드립니다).

대황(大黃)류 한약재의 기원 및 유통상황, 한방효능, 형태특징, 감별요점 등은 여기를 참조바랍니다.


written by : Jung-Hoon Kim. Division of Pharmacology, Pusan National Univ.

 

1. 장엽대황(掌葉大黃): 掌葉大黃 Rheum palmatum L.의 根과 根莖

 

① Anthraquinones (2.034~2.984%): 유리형 anthraquinones (0.037~1.155%) rhein1, aloe-emodin1, emodin1, physcion1, chrysophanol1; 결합형 anthraquinones (1.829~1.997%) pulmatin, physcion-8-O-glucoside, aloe-emodin-8-O-glucoside, chrysophanol-1-O-glucoside, chrysophanol-8-O-glucoside, emodin-1-O-glucoside, emodin-8-O-glucoside, rhein-8-O-glucoside, rheinoside A~D, physcion-8-O-β-D-gentiobioside, aloe-emodin-ω-O-β-D-glucoside, emodin diglucoside, aloe-emodin diglucoside, chrysophanol diglucoside, physcionin

대황(大黃) Rhei Radix et Rhizoma대황(大黃) Rhei Radix et Rhizoma
대황(大黃) Rhei Radix et Rhizoma

대황(大黃) Rhei Radix et Rhizoma대황(大黃) Rhei Radix et Rhizoma

② Dianthrones: palmidin A~C, sennidin A~C, rheidin A~C, sennoside A2~D

대황(大黃) Rhei Radix et Rhizoma

③ Stilbene glucosides: 3,4′,5-trihydroxystilbene-4′-O-β-D-glucopyranoside, 3,4,3′,5′-tetrahydroxystilbene-4-glucopyranoside, 4,3′,5′-trihydroxystilbene-4-(6″-galloyl)-glucopyranoside, 4′-O-methylpiceid, rhapontin

④ Phenolic glucosides: musizin-8-O-β-D-glucoside, 6-hydroxymusizin-8-O-β-D-glucoside, torachrysone-8-O-β-D-glucoside, torachrysone-8-O-β-D-(6′-oxalyl)-glucoside, rhaponticin

⑤ Butyrophenones: 4-(4′-hydroxyphenyl)-2-butanone-4′-O-β-D-glucopyranoside, phenylbutanone-glucoside-4-(p-hydroxyphenyl)-butanone-O-glucoside, 6-cinnamoylisolindleyin

⑥ Volatile compounds: 1,2-dimethoxybenzene, 2,3-dimethoxyphenol, 1,4-dimethoxybenzene, octanoic acid, dimethylnaphthalene, 1-methoxynaphthalene, trimethoxynaphthalene, hexadecane, palmitic acid, paeonol, α-copaene, methyl stearate, cadinene, methyl eugenol

⑦ Tannins: 1,6-digalloyl-2-cinnamoyl glucose, 1-galloyl-2-cinnamoyl glucose, (+)-catechin-5-O-glucoside, gallic acid-3-O-(6′-O-galloyl)-glucoside, procyanidin B-13′-O-gallate, (-)-epicatechin-3′-O-gallate, 2-O-cinnamoyl glucogallin, (-)-epicatechin-3-O-gallate

 

 

2. 탕구트대황(唐古特大黃): 唐古特大黃 Rheum tanguticum Maxim. ex Balf.의 根과 根莖

 

① Anthraquinones (6.250%): 유리형 anthraquinones (0.805%) rhein1, aloe-emodin1, emodin1, physcion1, chrysophanol1; 결합형 anthraquinones (5.455%) chrysophanol-1-O-glucoside, physcion-8-O-glucoside, emodin-6-O-glucoside, aloe-emodin-8-O-glucoside, rhein-8-O-glucoside, aloe-emodin-ω-O-β-D-glucoside, chrysophanol-8-O-β-D-glucoside, physcion-8-O-β-D-glucoside, emodin-8-O-β-D-glucoside

② Phenolic glucosides: musizin-8-O-β-D-glucoside, torachrysone-8-O-β-D-glucoside

③ Stilbene glucosides: 3,4′,5-trihydroxystilbene-4′-O-β-D-glucopyranoside, 3,4,3′,5′-tetrahydroxystilbene-4-glucopyranoside, 4,3′,5′-trihydroxystilbene-4-(6″-galloyl)-glucopyranoside

④ Butyrophenones: lindleyin, isolindleyin

⑤ Tannins: 1,6-digalloyl-2-cinnamoyl glucose, 1-galloyl-2-cinnamoyl glucose

 

3. 약용대황(藥用大黃): 藥用大黃 Rheum officinale Baill.의 根과 根莖

 

① Anthraquinones (4.490~5.750%): 유리형 anthraquinones (0.267~1.900%) rhein1, aloe-emodin1, emodin1, physcion1, chrysophanol1; 결합형 anthraquinones (3.850~4.223%) chrysophanol-1-O-β-D-glucoside, physcion-8-O-β-D-glucoside, emodin-6-O-β-D-glucoside, aloe-emodin-8-O-β-D-glucoside, rhein-8-O-β-D-glucoside, aloe-emodin-ω-O-β-D-glucoside

② Phenolic glucosides: musizin-8-O-β-D-glucoside, torachrysone-8-O-β-D-glucoside

③ Dianthrones: sennoside A2/B

④ Stilbene glucosides: 3,4′,5-trihydroxystilbene-4′-O-β-D-glucopyranoside

⑤ Chromones: 2,5-dimethyl-7-hydroxybenzopyran-γ-one, 5-carboxy-7-hydroxy-2-methylbenzopyran-γ-one

⑥ Tannins: 1,6-digalloyl-2-cinnamoyl glucose, 1-galloyl-2-cinnamoyl glucose

 


1,2센노시드 A(C42H38O20 : 862.74)로서 0.02% 이상 및 알로에에모딘(C15H10O5 : 270.24), 레인(C15H8O6 : 284.23), 에모딘(C15H10O5 : 270.24), 크리소파놀(C15H10O4 : 254.25), 파이시온(C16H12O5 : 284.27)의 합 1.5% 이상을 함유 [KP 11]

1총 anthraquinone(蒽醌)을 aloeemodin(芦荟大黄素, C15H10O5), rhein(大黄酸, C15H8O6), emodin(大黄素, C15H10O5), chrysophanol(大黄酚, C15H10O4)과 physcion(大黄素甲醚, C16H12O5)의 총량으로서 1.5% 이상 함유하며, 유리 anthraquinone(蒽醌)을 aloeemodin(芦荟大黄素, C15H10O5), rhein(大黄酸, C15H8O6), emodin(大黄素, C15H10O5), chrysophanol(大黄酚, C15H10O4)과 physcion(大黄素甲醚, C16H12O5)의 총량으로서 0.20% 이상 함유. 대황의 음편에서는 유리 anthraquinone을 0.35% 이상 함유 [CP 2015]

1aloe-emodin, rhein, emodin, chrysophanol 및 physcion의 합 1.5% 이상을 함유 [THP II]

1aloe-emodin(蘆薈大黃素, C15H10O5), chrysophanol(大黃酚, C15H10O4), emodin(大黃素, C15H10O5), physcion(大黃素甲醚, C16H12O5)과 rhein(大黃酸, C15H8O6)의 총량을 1.5% 이상 함유 [HKCMMS 2]

2sennoside(センノシド) A (C42H38O20: 862.74)를 0.25% 이상 함유 [JP 17]

1안트라키논화합물이 크리쏘판산(C15H10O4)으로 계산하여 4.0%이상 함유 [DP VII]