한약성분정보는 ‘운곡본초학 수재 한약재의 화학성분 제 2판(김정훈 외, 도서출판 우석, 2016)’의 내용을 발췌 및 정리하여 게시하였습니다. 해당 한약재에 함유된 성분 중 이차대사산물(secondary metabolites)을 주요 골격으로 구분하여 제시하였습니다 (성분의 골격 분류 방법에는 다양한 의견이 존재함을 일러드립니다).

천궁(川芎)류 한약재의 기원 및 유통상황, 한방효능, 형태특징, 감별요점 등은 여기를 참조바랍니다.

written by : Jung-Hoon Kim. Division of Pharmacology, Pusan National Univ.

1. 당천궁(唐川芎): 川芎 Ligusticum sinense ‘Chuanxiong’ S.H.Qiu & al.의 뿌리줄기(根莖)

① Lactones: chuanxiongzine (tetramethylpyrazine), perlolyrine[1-(5-hydroxymethyl-2-furyl)-9H-pyrido[3,4-b]-indole], ligustilide, z-ligustilide¹, wallichilide, 3-butylidenephthalide, 3-butylidene-7-hydroxyphthalide, butylphthalide, (3S)-3-butyl-4-hydroxyphthalide, (3S)-chunxiongol, 3-n-butyl-3,6,7-trihydroxy-4,5,6,7-tetrahydrophthalide, neocindilide, senkyunolide, senkyunolide B~G, senkyunolide H (cis-6,7-dihydroxyligustilide), senkyunolide Ⅰ(trans-6,7-dihydroxyligustilide), senkyunolide J~P, (E)-senkyunolide E

② Quinoids: senkyunone

③ Phenolic compounds: 2-methoxy-4-(3-methoxy-1-propenyl)-pheneol, 2-(1-oxopentyl)-benzoic acid methyl ester, 5-hydroxymethyl-6-endo-3-methoxy-4-hydroxyphenyl-8-oxa-bicyclo(3.2.1)-oct-3-one, 4-hydroxy-3-methoxy styrene, 1-hydroxy-1-(3-methoxy-4-hydroxyphenyl)-ethane, chunxiongol, vanillin

④ Phenolic acids: 4-hydroxybenzoic acid, vanillic acid, caffeic acid, protocatechuic acid, ferulic acid², sedanonic acid

⑤ Anthraquinones: chrysophanic acid

⑥ Alkaloids: perlolyrine

⑦ Fatty acids: palmitic acid, linoleic acid

⑧ β-Carbolines: 1-acetyl-β-carboline

⑨ Sesquierpenes: spathulenol

⑩ Steroids: β-sitosterol

¹Z-ligustilide(藁本內酯, C₁₂H₁₄O₂)를 0.47% 이상 함유 _{[HKCMMS 2]}

²ferulic acid(阿魏酸, C₁₀H₁₀O₄)를 0.10% 이상 함유 _{[CP 2015],} ferulic acid를 0.07% 이상 함유 _{[THP II]}